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Bacterial two-component systems and phosphorelays are woven into the fabric of cellular regulatory mechanisms ensuring homeostatic equilibrium under a wide variety of environmental conditions (reviewed in references [13][1], [15][2], [18][3], [19][4], [23][5], and [28][6]). Of the individual two-

Essentiality, Bypass, and Targeting of the YycFG (VicRK) Two-Component Regulatory System in Gram-Positive Bacteria