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Sequencing of the first Escherichia coli (K-12) genome revealed that there were ∼4,300 open reading frames (ORFs) expected to encode proteins and many stable RNA genes that encode rRNA and tRNA ([3][1]). Surprisingly, at that time only 43% of the ORFs had been previously described, and 38% could

Global Approaches for Finding Small RNA and Small Open Reading Frame Functions