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A characteristic feature of biofilm formation is the production of a protective extracellular polymeric matrix. In the gram-positive bacteriumBacillus subtilis , the biofilm matrix is synthesized by the products of theepsABCDEFGHIJKLMNO operon (hereafter called theeps operon) andyqxM-sipW-tasA loci. Transcription from these operons is repressed by two key regulators, AbrB and SinR. Relief of inhibition is necessary to allow biofilm formation to proceed. Here we present data indicating that Abh, a sequence and structural homologue of AbrB, regulates biofilm architecture byB .subtilis when colony morphology and pellicle formation are assessed. Data indicating thatabh expression is dependent on the environmental signals that stimulate the activity of the extracytoplasmic function σ-factor σX are shown. We demonstrate that expression ofslrR , the proposed activator ofyqxM transcription, is positively controlled by Abh. Furthermore, Abh is shown to activate transcription from the promoter of theep s operon through its control of SlrR. These findings add to the increasingly complex transcriptional network that controls biofilm formation byB .subtilis .

σ X Is Involved in Controlling Bacillus subtilis Biofilm Architecture through the AbrB Homologue Abh

σ ^X Is Involved in Controlling Bacillus subtilis Biofilm Architecture through the AbrB Homologue Abh