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CO2 is a ubiquitous product of cellular metabolism and an essential substrate for carboxylation reactions. The pyruvate dehydrogenase complex (PDHC) catalyzes a central metabolic reaction contributing to the intracellular CO2 /HCO3 – pool in many organisms. In this study, we used a PDHC-deficient strain ofCorynebacterium glutamicum , which additionally lacked pyruvate carboxylase (ΔaceE Δpyc ). This strain featured a &gt;15-h lag phase during growth on glucose-acetate mixtures. We used this strain to systematically assess the impact of alterations in the intracellular CO2 /HCO3 – pool on growth in glucose-acetate medium. Remarkably, all measures enhancing CO2 /HCO3 – levels successfully restored growth. These results emphasize the strong impact of the intracellular CO2 /HCO3 – pool on metabolic flux, especially in strains exhibiting low endogenous CO2 production rates.

journal of bacteriology

Impact of CO 2 /HCO 3 – Availability on Anaplerotic Flux in Pyruvate Dehydrogenase Complex-Deficient Corynebacterium glutamicum Strains