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FNR-dependent activation of the Escherichia coli K-12 nrf promoter is downregulated by the nitric oxide-sensitive NsrR protein together with the nucleoid-associated protein IHF, which bind to overlapping targets adjacent to the DNA site for FNR. The NsrR target is inactivated by mutation at the Salmonella enterica serovar Typhimurium nrf promoter.

journal of bacteriology

Down-Regulation of the <i>Escherichia coli</i> K-12 <i>nrf</i> Promoter by Binding of the NsrR Nitric Oxide-Sensing Transcription Repressor to an Upstream Site

Down-Regulation of the Escherichia coli K-12 nrf Promoter by Binding of the NsrR Nitric Oxide-Sensing Transcription Repressor to an Upstream Site