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Many nucleases and helicases are engaged in homologous recombination-mediated DNA repair. Previousin vitro analyses in archaea indicated that NurA and HerA are the recombination-related nuclease and helicase. However, their cellular function had not been fully understood, especially in bacterial cells. In this study, we performedin vivo analyses to address the cellular function ofnurA andherA in an extremely thermophilic bacterium,Thermus thermophilus . As a result,T. thermophilus NurA and HerA exhibited an interfering effect on the repair of several instances of DNA damage in the cell, which is in contrast to the results in archaea. This finding will facilitate our understanding of the diverse cellular functions of the recombination-related nucleases and helicases.

Resistance to UV Irradiation Caused by Inactivation of nurA and herA Genes in Thermus thermophilus