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The outer membrane of Gram-negative bacteria acts as an effective barrier against toxic compounds, and therefore compromising this structure could increase sensitivity to currently available antibiotics. In this study, we show that the Mla pathway, a system involved in maintaining the integrity of the outer membrane, is genetically and functionally different inBurkholderia cepacia complex species compared to that in other proteobacteria. Mutants inmla genes ofBurkholderia cenocepacia orBurkholderia dolosa were sensitive to Gram-positive antibiotics, while this effect was not observed inEscherichia coli orPseudomonas aeruginosa . The Mla pathway inBurkholderia species may represent an ideal genus-specific target to address their intrinsic antimicrobial resistances.

journal of bacteriology

The Mla Pathway Plays an Essential Role in the Intrinsic Resistance of Burkholderia cepacia Complex Species to Antimicrobials and Host Innate Components