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This study was undertaken to evaluate the potential of a cryptococcal culture filtrate antigen, cryptococcin C184, for detecting delayed hypersensitivity inCryptococcus neoformans -injected animals. The antigen was tested on guinea pigs which had received saline orC. neoformans and on animals sensitized toHistoplasma capsulatum, Blastomyces dermatitidis, Candida albicans , orSporothrix schenckii. A delayed-type hypersensitivity response was elicited by cryptococcin C184 inC. neoformans -injected guinea pigs, whereas no indurations or erythemas were seen at 48 h after skin testing of saline controls or heterologously sensitized guinea pigs. Besides being specific forCryptococcus , the antigen showed a high degree of sensitivity and was reproducible. Footpad tests were conducted with the antigen on mice which had previously received either 105 viableC. neoformans cells or saline. Delayed hypersensitivity was indicated in theC. neoformans -injected mice by the increase in thickness of antigen-injected footpads when compared with the saline-injected footpads. In control mice, antigen- and saline-injected footpads were comparable in thickness 24 h after injection. Mice sensitized toB. dermatitidis were footpad tested with C184, and no cross-reactivity was demonstrated.

Skin Testing of Guinea Pigs and Footpad Testing of Mice With a New Antigen for Detecting Delayed Hypersensitivity to Cryptococcus neoformans