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The influence of total, F1, and F3 histones on the primary antibody response in guinea pigs to vaccination with influenza virus A/2/Aichi/2/68 (H3 N2) was investigated. It was found that histones can greatly reduce the immunoglobulin (Ig) M and, to a smaller degree, the IgG antibody response. The immunosuppressive effect of histones was found to depend critically on the dose of virus used for vaccination, on the type and dose of histones, and on the schedule of histone application.

Influence of Histones on the Antibody Response in Guinea Pigs to Vaccination with A/Aichi/2/68 (H3 N2) Influenza Virus