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H2-M3-restricted CD8+ T cells can exhibit cross-reactivity to different bacterially derived N-formylmethionine peptides. The extent of this promiscuity is unclear. We deleted the nonredundant fMIVTLF epitope and found that Listeria monocytogenes still primed fMIVTLF-specific T cells. Thus, cross-reactivity appears to be a more general characteristic of H2-M3-restricted T cells.

Cross-Recognition ofN-Formylmethionine Peptides Is a General Characteristic of H2-M3-Restricted CD8+T Cells

Cross-Recognition ofN-Formylmethionine Peptides Is a General Characteristic of H2-M3-Restricted CD8⁺T Cells