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Peritoneal exudate cells of mice were stimulated with a streptomycin-dependent Mycobacterium tuberculosis strain, 18b. Gamma interferon production by natural killer cells depending on interleukin-12 and interleukin-18 was induced only in the presence of a high dose of streptomycin. This study suggested the requirement of active bacterial metabolism for this host response.

Streptomycin-Dependent Exhibition of Cytokine-Inducing Activity in Streptomycin-DependentMycobacterium tuberculosisStrain 18b