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Cryptococcus neoformans is a human fungal pathogen that has two mating types (a and alpha). Experiments have shown that in some backgrounds alpha strains are more virulent than a strains. Our studies reveal that the only known alpha-specific factor, SXI1alpha, is not necessary for virulence.

The α-Specific Cell Identity Factor Sxi1α Is Not Required for Virulence of Cryptococcus neoformans