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A Salmonella enterica serovar Typhimurium aroA-deficient delivery system was used to target the immunosuppressive protein Salp15 to antigen-presenting cells. In vitro and in vivo infections with Salp15-containing Salmonella resulted in an impaired CD4(+)-T-cell activation, suggesting that the protein was produced by antigen-presenting cells in a physiologically active form.

Delivery of the Immunosuppressive Antigen Salp15 to Antigen-Presenting Cells bySalmonella entericaSerovar TyphimuriumaroAMutants