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Previous studies demonstrated that the high-mannose oligosaccharide N linked to the Chlamydia major outer membrane protein inhibited the attachment and infectivity of the organism. The present study showed that cleavage of the glycan with N-glycanase decreased the attachment and infectivity of chlamydial organisms in human epithelial and endothelial cells.

infection and immunity

Cleavage of the N-Linked Oligosaccharide from the Surfaces of <i>Chlamydia</i> Species Affects Attachment and Infectivity of the Organisms in Human Epithelial and Endothelial Cells

Cleavage of the N-Linked Oligosaccharide from the Surfaces of Chlamydia Species Affects Attachment and Infectivity of the Organisms in Human Epithelial and Endothelial Cells