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Oral immunization of mice with Escherichia coli-expressed Plasmodium yoelii merozoite surface protein 4/5 or the C-terminal 19-kDa fragment of merozoite surface protein 1 induced systemic antibody responses and protected mice against lethal malaria infection. A combination of these two proteins administered orally conferred improved protection compared to that conferred by either protein administered alone.

infection and immunity

Oral Immunization with a Combination of<i>Plasmodium yoelii</i>Merozoite Surface Proteins 1 and 4/5 Enhances Protection against Lethal Malaria Challenge

Oral Immunization with a Combination ofPlasmodium yoeliiMerozoite Surface Proteins 1 and 4/5 Enhances Protection against Lethal Malaria Challenge