Open AccessYersinia pestisTonB: Role in Iron, Heme, and Hemoprotein Utilization
Author(s) -
Robert D. Perry,
Jessica Shah,
Scott W. Bearden,
Jan M. Thompson,
Jacqueline D. Fetherston
Publication year - 2003
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.71.7.4159-4162.2003
Subject(s) - hemin , yersinia pestis , siderophore , heme , biology , bacterial outer membrane , microbiology and biotechnology , yersinia , ferritin , biochemistry , bacteria , virulence , escherichia coli , genetics , enzyme , gene
In Yersinia pestis, the siderophore-dependent yersiniabactin (Ybt) iron transport system and heme transport system (Hmu) have putative TonB-dependent outer membrane receptors. Here we demonstrate that hemin uptake and iron utilization from Ybt are TonB dependent. However, the Yfe iron and manganese transport system does not require TonB.
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