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In murine Lyme borreliosis, the absence of gamma delta T lymphocytes augments the T helper cell 2 type humoral response but does not alter disease susceptibility. Arthropod transmission of Borrelia burgdorferi spirochetes results in similar antibody isotypes when gamma delta T cells are present, suggesting that vector effects can negate gamma delta T-cell functions in vivo.

Humoral Immunity Reflects Altered T Helper Cell Bias inBorrelia burgdorferi-Infected γδ T-Cell-Deficient Mice