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Listeria epitope-specific helper T (Th) cells were able to be primed and induced in vivo by immunization with a plasmid carrying an invariant chain (Ii) gene whose class II-associated invariant chain peptide (CLIP) region was replaced by a Listeria Th epitope. Immunization of C3H/He mice with an Ii-LLO 215-226 plasmid induced specific interferon-gamma- and interleukin 2-producing Th cells and conferred significant protective immunity against listerial infection.

infection and immunity

Induction of Protective Immunity to<i>Listeria monocytogenes</i>by Immunization with Plasmid DNA Expressing a Helper T-Cell Epitope That Replaces the Class II-Associated Invariant Chain Peptide of the Invariant Chain

Induction of Protective Immunity toListeria monocytogenesby Immunization with Plasmid DNA Expressing a Helper T-Cell Epitope That Replaces the Class II-Associated Invariant Chain Peptide of the Invariant Chain