Open AccessNovel Laminin-Binding Protein of Streptococcus pyogenes , Lbp, Is Involved in Adhesion to Epithelial Cells
Author(s) -
Yutaka Terao,
Shigetada Kawabata,
Eiji Kunitomo,
Ichirô Nakagawa,
Shigeyuki Hamada
Publication year - 2002
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.70.2.993-997.2002
Subject(s) - streptococcus pyogenes , bacterial adhesin , biology , laminin , microbiology and biotechnology , adhesion , mutant , gene , virulence , bacteria , extracellular matrix , genetics , chemistry , organic chemistry , staphylococcus aureus
The lbp gene, which encodes a laminin-binding protein (Lbp) of Streptococcus pyogenes, was found in all S. pyogenes M types. An Lbp-deficient mutant showed a significantly lower efficiency of adhesion to HEp-2 cells than did the wild-type strain. These results indicate that Lbp is one of the important S. pyogenes adhesins.
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