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Interleukin-2 (IL-2)/IL-15 receptor beta (IL-15R beta)(-/-) mice were susceptible to infection with avirulent Salmonella enterica subsp. enterica serovar Choleraesuis, whereas IL-2(-/-) mice were resistant. A natural killer cell response was not evident for both types of deficient mice. A Th1 response was detected in IL-2(-/-) but not in IL-2/IL-15R beta(-/-) mice infected with Salmonella, suggesting that IL-2/IL-15R beta signaling is important for the generation of protective Th1 cells.

infection and immunity

Mice Lacking Interleukin-2 (IL-2)/IL-15 Receptor β Chain Are Susceptible to Infection with Avirulent<i>Salmonella enterica</i>subsp.<i>enterica</i>Serovar Choleraesuis but Mice Lacking IL-2 Are Resistant

Mice Lacking Interleukin-2 (IL-2)/IL-15 Receptor β Chain Are Susceptible to Infection with AvirulentSalmonella entericasubsp.entericaSerovar Choleraesuis but Mice Lacking IL-2 Are Resistant