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Deleting transmembrane alpha-helix motifs from Plasmodium falciparum sporozoite surface protein (SSP-2) allowed its secretion from Salmonella enterica serovar Typhimurium SL3261 and S. enterica serovar Typhi CVD 908-htrA by the Hly type I secretion system. In mice immunized intranasally, serovar Typhimurium constructs secreting SSP-2 stimulated greater gamma interferon splenocyte responses than did nonsecreting constructs (P = 0.04).

infection and immunity

Expression, Extracellular Secretion, and Immunogenicity of the<i>Plasmodium falciparum</i>Sporozoite Surface Protein 2 in<i>Salmonella</i>Vaccine Strains

Expression, Extracellular Secretion, and Immunogenicity of thePlasmodium falciparumSporozoite Surface Protein 2 inSalmonellaVaccine Strains