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Fibronectin-binding protein I (SfbI) of Streptococcus pyogenes binds to mouse immunoglobulin G (IgG) but not to IgA or IgM in a nonimmune fashion. The fibronectin-binding domains of SfbI were responsible for this activity, which was targeted to the IgG F(ab')(2) fragment. SfbI also binds to B cells but not to CD4(+) or CD8(+) lymphocytes.

Nonimmune Interaction of the SfbI Protein ofStreptococcus pyogeneswith the Immunoglobulin G F(ab′)2Fragment

Nonimmune Interaction of the SfbI Protein ofStreptococcus pyogeneswith the Immunoglobulin G F(ab′)₂Fragment