Open AccessMTSA-10, the Product of the Rv3874 Gene of Mycobacterium tuberculosis , Elicits Tuberculosis-Specific, Delayed-Type Hypersensitivity in Guinea Pigs
Author(s) -
Roberto Colangeli,
John S. Spencer,
Pablo Bifani,
Alan Williams,
Konstantin P. Lyashchenko,
Marc A. Keen,
Preston J. Hill,
John T. Belisle,
Maria Laura Gennaro
Publication year - 2000
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.68.2.990-993.2000
Subject(s) - tuberculosis , mycobacterium bovis , mycobacterium tuberculosis , tuberculin , biology , antigen , vaccination , microbiology and biotechnology , bcg vaccine , mycobacterium tuberculosis complex , virology , immunology , mycobacterium , delayed hypersensitivity , latent tuberculosis , medicine , pathology
In a search for new skin test reagents specific for tuberculosis, we found that the antigen encoded by gene Rv3874 of Mycobacterium tuberculosis elicited delayed-type hypersensitivity in M. tuberculosis-infected guinea pigs but not in control animals immunized with Mycobacterium bovis bacillus Calmette-Guérin (BCG) or Mycobacterium avium. The antigen, which was named MTSA-10 (for M. tuberculosis-specific antigen 10), is a prime candidate for a component of a new tuberculin that will allow discrimination by a skin test of latent M. tuberculosis infection from vaccination with BCG or from sensitization with environmental, nontuberculous mycobacteria.
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