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Lesion size, cellular infiltration, and tissue parasitism in the footpads of BALB/c mice infected withLeishmania major were all dramatically inhibited during acute but not chronic infection withToxoplasma gondii . Similarly, acute but not chronic toxoplasmosis at the time of infection withL. major had a strong inhibitory effect on development of acquired immune responses mediated by Th2 lymphocytes. In contrast, no major changes inLeishmania -specific Th1-mediated responses were observed in mice coinfected withT. gondii.

infection and immunity

Coinfection with<i>Toxoplasma gondii</i>Inhibits Antigen-Specific Th2 Immune Responses, Tissue Inflammation, and Parasitism in BALB/c Mice Infected with<i>Leishmania major</i>

Coinfection withToxoplasma gondiiInhibits Antigen-Specific Th2 Immune Responses, Tissue Inflammation, and Parasitism in BALB/c Mice Infected withLeishmania major