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Cryptosporidium parvum is an important cause of diarrhea in humans and several animal species. Prostaglandins play a central role in regulating intestinal fluid secretion in animal models of cryptosporidiosis, but their cellular sources and mechanisms of induction are unclear. Here, we show thatC. parvum infection directly activates prostaglandin H synthase 2 expression and prostaglandin E2 and F2α production in human intestinal epithelial cells.

infection and immunity

Human Intestinal Epithelial Cells Respond toCryptosporidium parvumInfection with Increased Prostaglandin H Synthase 2 Expression and Prostaglandin E2and F2αProduction