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To identify genes encoding adhesins that mediate the binding ofCandida albicans to endothelial cells, a genomic library from this organism was constructed and used to transformSaccharomyces cerevisiae . These transformed organisms were screened for adherence to endothelial cells, and a highly adherent clone was identified. The adherence of this clone to endothelial cells was over 100-fold greater than that of controlS. cerevisiae transformed with the empty plasmid. This clone also exhibited enhanced adherence to epithelial cells. TheC. albicans gene contained within this clone was found to beALS1 . These results indicate thatALS1 may encode a candidal adhesin.

Expression of the Candida albicans Gene ALS1 in Saccharomyces cerevisiae Induces Adherence to Endothelial and Epithelial Cells