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Mycobacterium tuberculosis readily activates both CD4+ and Vδ2+ γδ T cells. Despite similarity in function, these T-cell subsets differ in the antigens they recognize and the manners in which these antigens are presented byM. tuberculosis -infected monocytes. We investigated mechanisms of antigen processing ofM. tuberculosis antigens to human CD4 and γδ T cells by monocytes. Initial uptake ofM. tuberculosis bacilli and subsequent processing were required for efficient presentation not only to CD4 T cells but also to Vδ2+ γδ T cells. For γδ T cells, recognition ofM. tuberculosis -infected monocytes was dependent on Vδ2+ T-cell-receptor expression. Recognition ofM. tuberculosis antigens by CD4+ T cells was restricted by the class II major histocompatibility complex molecule HLA-DR. Processing ofM. tuberculosis bacilli for Vδ2+ γδ T cells was inhibitable by Brefeldin A, whereas processing of soluble mycobacterial antigens for γδ T cells was not sensitive to Brefeldin A. Processing ofM. tuberculosis bacilli for CD4+ T cells was unaffected by Brefeldin A. Lysosomotropic agents such as chloroquine and ammonium chloride did not affect the processing ofM. tuberculosis bacilli for CD4+ and γδ T cells. In contrast, both inhibitors blocked processing of soluble mycobacterial antigens for CD4+ T cells. Chloroquine and ammonium chloride insensitivity of processing ofM. tuberculosis bacilli was not dependent on the viability of the bacteria, since processing of both formaldehyde-fixed dead bacteria and mycobacterial antigens covalently coupled to latex beads was chloroquine insensitive. Thus, the manner in which mycobacterial antigens were taken up by monocytes (particulate versus soluble) influenced the antigen processing pathway for CD4+ and γδ T cells.

Processing ofMycobacterium tuberculosisBacilli by Human Monocytes for CD4+αβ and γδ T Cells: Role of Particulate Antigen

Processing ofMycobacterium tuberculosisBacilli by Human Monocytes for CD4⁺αβ and γδ T Cells: Role of Particulate Antigen