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Plasmodium falciparum antigens SERP, HRPII, MSAI, and 41-3 have shown promise as vaccine components. This study aimed at reproducing and extending previous results using three hybrid molecules. Antibody responses were reproduced inAotus monkeys, but solid protection from aP. falciparum blood-stage challenge that showed an unintendedly enhanced pathogenicity was not observed.

infection and immunity

Immunization of <i>Aotus</i> Monkeys with Recombinant <i>Plasmodium falciparum</i> Hybrid Proteins Does Not Reproducibly Result in Protection from Malaria Infection

Immunization of Aotus Monkeys with Recombinant Plasmodium falciparum Hybrid Proteins Does Not Reproducibly Result in Protection from Malaria Infection