Open AccessNonimmune binding of equine immunoglobulin by the causative organism of contagious equine metritis, Taylorella equigenitalis
Author(s) -
P R Widders,
Christopher Stokes,
T.J. Newby,
F.J. Bourne
Publication year - 1985
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.48.2.417-421.1985
Subject(s) - biology , antibody , immunoglobulin g , immunoglobulin d , virology , immunoglobulin m , microbiology and biotechnology , epitope , immunology , b cell
This study identifies nonimmune binding of equine immunoglobulin by the causative organism of contagious equine metritis. Immunoglobulin binding to the bacterium was strongest for immunoglobulin G (IgG) and less for IgM; IgA was not bound. Binding of equine IgG was inhibited by human IgG, but not by IgG of domestic animals. Immunoglobulin binding by the bacterium appeared to be directed towards an epitope in the hinge region of the immunoglobulin molecule.
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