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The protein II (P.II) outer membrane proteins of Neisseria gonorrhoeae, which have been implicated in gonococcal pathogenesis, have been previously shown to undergo a type of phase variation in which expression of any of several different forms of the proteins may be switched on or off. We identified six electrophoretically distinct forms of P.II proteins (designated P.IIa through P.IIf) within strain FA1090, and we isolated colonial variants of FA1090 that expressed only one of the six different P.II protein forms. Two monoclonal antibodies that bound specifically and differentially to P.II proteins were produced. One antibody bound to proteins P.IIb and P.IId and was bactericidal for all colonial variants expressing P.IIb. The second antibody bound to P.IIa and was bactericidal for colonial variants expressing P.IIa. P.II protein profiles of survivors of antibody killing indicated that multiple P.II protein species may be expressed on a single bacterium and that P.II protein switching in the gonococcus is nonrandom.

Characterization of Neisseria gonorrhoeae protein II phase variation by use of monoclonal antibodies