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Homozygous (bg/bg) and heterozygous (bg/+) beige mice were infected with Toxoplasma gondii, and splenic and peritoneal natural killer (NK) cell activities were assayed against YAC-1 lymphoma (NK-YAC) and thymocyte (NK-THY) targets. Although uninfected bg/bg mice were devoid of NK-YAC activity when compared with bg/+ mice, NK-THY activity was at a completely normal level. Both effector cells showed NK-1.2+ Thy-1.2 +/- asialo GM1+ asialo GM2+ phenotype. T. gondii infection induced a marked augmentation in splenic NK-YAC activity of bg/+ mice, whereas a slight increase was shown in the bg/bg mouse spleen cells. On the other hand, the infection did not change the splenic NK-THY activity of either strain of mice. An increased expression of Thy-1.2 antigen was shown on both NK-THY and NK-YAC effector cells from the infected mouse spleen. The T. gondii-induced augmentation was dramatic in the peritoneal cavity of the both mice. The activated peritoneal NK cells were of the NK-1.2- Thy-1.2+ asialo GM1 +/- asialo GM2+ phenotype and were considered to be generated from functionally inactive peritoneal cells. Splenic effector cells obtained from the infected mice were selectively depleted with target cell monolayer, whereas peritoneal cells from the infected mice were strongly absorbed by the target monolayers without selectivity. A weak but significant interferon (IFN) titer was detected in the peritoneum, but not in the spleen, of the infected mice. Most of the IFN titer was acid labile. Treatment with anti-IFN-alpha/beta resulted in partial decline of both NK and IFN activities of bg/bg mice, but not bg/+ mice. Thus, involvement of both IFN-alpha/beta and IFN-gamma in the generation of peritoneal NK cells and IFN-independent augmentation of splenic NK cells in toxoplasmosis were suggested.

Toxoplasma-induced activities of peritoneal and spleen natural killer cells from beige mice against thymocytes and YAC-1 lymphoma targets