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N-Acetylmuramyl-l-alanyl-d-isoglutamine (MDP) induced the chemotaxis of human blood monocytes without mediation of serum complement. Specificity (dependency on chemical structure) of the chemotactic activity of MDP was evidenced by a negligible activity of analogs lacking most of the immunomodulating activities of MDP.

Possible Chemotaxis of Human Monocytes by N -Acetylmuramyl- l -Alanyl- d -Isoglutamine