English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

A rabbit was immunized with large amounts of the lactate dehydrogenase-elevating virus (LDV) over a 9-month period. The plasma from this rabbit possessed an anti-LDV IgG titer of 1:80,000 as measured by the enzyme-linked immunosorbent assay (ELISA) method and a neutralizing titer of 1:1,000 for the homologous strain of LDV. LDV neutralization at 4 degrees C followed single-hit kinetics. In contrast, mouse anti-LDV IgG in plasma of chronically LDV-infected mice failed to neutralize LDV at 4 degrees C and neutralization at 37 degrees C was slow, biphasic, and inefficient compared with the neutralization caused by rabbit anti-LDV IgG, even though high levels of anti-LDV IgG were detectable in mouse plasma by the ELISA method. Rabbit anti-LDV IgG neutralized one heterologous strain of LDV as rapidly as it did the homologous strain, but failed to significantly neutralize five other strains of LDV, all of which were originally isolated from different mouse strains bearing transplantable tumors. The results indicate clear serological differences between LDV strains. Cross-reactions between the strains, however, were observed by ELISA, using the antibody induced during persistent infection of mice with each LDV strain. Immunoglobulin M (IgM) from mice infected for 15 days with the various strains bound equally to our LDV strain. IgG obtained from 2-month-infected mice also cross-reacted, but to a varying extent which partly correlated with the specificity detected by neutralization. Both rabbit and mouse anti-LDV IgG enhanced the infectivity of LDV at a low multiplicity of infection for primary cultures of peritoneal mouse macrophages.

Immune response to lactate dehydrogenase-elevating virus: serologically specific rabbit neutralizing antibody to the virus