English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Granulocytopenia seen during human pneumococcal disease is associated with a worsened prognosis. Streptococcus pneumoniae type 1 reduces circulating granulocytes and induces pulmonary leukostasis in rabbits. We studied which type 1 pneumococcal fraction(s) might be responsible for the reduction in circulating granulocytes. Rabbits were challenged intravenously with nonpyrogenic sterile saline, sonicated type 1 pneumococci, capsular polysaccharide from type 1 pneumococci, or cell walls from type 1 pneumococci. Nonviable pneumococci caused a mean decrease in blood granulocytes of 64% as compared with a mean increase of 124% in saline-injected controls, a difference significant at P less than 0.001. Pneumococcal cell walls induced significant decreases in circulating granulocytes at all doses tested when compared with saline-injected controls, whereas capsular polysaccharide induced no reduction in granulocytes. On a weight-for-weight basis, cell wall induced significantly more granulocyte reduction than did capsular polysaccharide at doses of either 10 mg (P less than 0.01) or 20 mg (P less than 0.005). A nonencapsulated pneumococcus also induced a profound granulocyte reduction (mean decrease in blood granulocytes, 88%) in the absence of detectable circulating polysaccharide. The cell wall fraction of S. pneumoniae type 1 was a more effective constituent in promoting the reduction in circulating granulocytes in rabbits.

Reduction of circulating granulocytes induced by type 1 pneumococcal cell walls in New Zealand white rabbits