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Since Staphylococcus aureus delta toxin previously had been shown to increase the cyclic adenosine 3',5'-monophosphate (cAMP) content of guinea pig ileum, the effect of delta toxin on such cAMP-mediated responses as morphogenesis and steroidogenesis in cultured tissue cells was examined. In contrast to cholera toxin, delta toxin did not cause spindling of Chinese hamster ovary cells. Unlike adrenocorticotropin or cholera toxin, delta toxin was unable to cause rounding of Y-1 adrenal cells or to promote steroid production by the cells. S. aureus alpha toxin and enterotoxin B were also unable to cause rounding of Y-1 adrenal cells. Omission of Ca2+ from the media still allowed for increased steroid production by adrenocorticotropin but not by delta toxin. Delta toxin at concentrations greater than 10 micrograms/ml did cause lysis of both Chinese hamster ovary and Y-1 adrenal cells. These findings suggest that the increase in intestinal cAMP levels caused by delta toxin is mediated through a mechanism different from that initiated by cholera toxin.

Effect of Staphylococcus aureus delta toxin on Chinese hamster ovary cell morphology and Y-1 adrenal cell morphology and steroidogenesis