English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

An experimental model was established using the terminal ileum of the rat for characterizing and studying the effects of crude cell-free extract from Clostridium perfringens upon physiological and histological parameters involved in the transport process. Further work was done with the model system using purified enterotoxin (protein) from the cell extract. Using an in vivo perfusion technique it was found that crude extract induces a reversal of net transport, from absorption in controls to secretion, of water, sodium, and chloride. Glucose absorption was greatly inhibited, whereas potassium and bicarbonate transports were unaffected. Crude extract also caused histological damage to the villus epithelium by denuding the villus tips, thereby leaving the lamina propria exposed. Similar responses in transport of water, sodium, chloride, bicarbonate, and glucose were caused by purified toxin. Little or no histological damage resulted from the pure toxin activity. However, the toxin was shown to have the capacity to denude villus tips under the proper experimental conditions.

In Vivo Effects of Clostridium perfringens Enteropathogenic Factors on the Rat Ileum