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At 26 h after inoculation of rats withDiplococcus pneumoniae , the serum concentrations of 10 and 20 individual amino acids were lower than corresponding values observed in pair-fed controls. In contrast, only 2 of 20 serum amino acids were similarly decreased in rats inoculated withSalmonella typhimurium. Despite these serum differences, a greater accumulation of labeled non-metabolizable amino acids occurred in the livers of rats infected withS. typhimurium. These data suggested a greater increase in the flux of amino acids from muscle to liver in the rats infected withS. typhimurium as compared to those infected withD. pneumoniae. A similar increase in serum protein synthesis was observed in rats infected withD. pneumoniae orS. typhimurium. However, with the latter infection, a larger percentage of the amino acids appeared to be utilized as a source of energy in addition to their role as precursors of proteins.

Amino Acid Flux and Protein Synthesis After Exposure of Rats to Either Diplococcus pneumoniae or Salmonella typhimurium