Open AccessSelection for Simple Major Surface Protein 2 Variants during Anaplasma marginale Transmission to Immunologically Naïve Animals
Author(s) -
Guy H. Palmer,
James E. Futse,
Christina K. Leverich,
Donald P. Knowles,
Fred R. Rurangirwa,
Kelly A. Brayton
Publication year - 2007
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.01801-06
Subject(s) - anaplasmataceae , biology , anaplasmosis , anaplasma , antigenic variation , transmission (telecommunications) , selection (genetic algorithm) , acquired immune system , pathogen , immunity , antigen , immune system , surface protein , virology , genetics , artificial intelligence , computer science , electrical engineering , tick , engineering
Anaplasma marginale , a rickettsial pathogen, evades clearance in the animal host by antigenic variation. Under immune selection,A. marginale expresses complex major surface protein 2 mosaics, derived from multiple donor sequences. However, these mosaics have a selective advantage only in the presence of adaptive immunity and are rapidly replaced by simple variants following transmission.