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The ability of 111Streptococcus agalactiae strains to bind to human fibrinogen was quantified. We correlated the percentages of bacteria that bound to immobilized fibrinogen with fibrinogen-binding (fbs ) gene characteristics of strains and with clinical origin, serotypes, and phylogenetic positions of strains. Percentages varied from 0.4 to 29.9%. Fifty-five strains (49.5%) had thefbsB gene sensu stricto described by Gutekunst et al. (Infect. Immun., 72:3495-3504, 2004), allowing adhesion to human fibrinogen, and all of the other strains had anfgag variant gene. Ninety strains (81.1%) had afbsA gene and 55 of them also had thefbsB gene. The other 21 strains (18.9%) had a truncated form offbsA without thefbsB gene sensu stricto. The numbers of 48-nucleotide repeat sequences (rs) in thefbsA gene varied from 2 to 26. The population of strains with the highest ability to bind to human fibrinogen significantly more frequently had thefbsB gene sensu stricto and 4 to 7 rs in thefbsA gene (P &lt; 0.05). However, the single strain that carried the highest number of rs (26 rs) in thefbsA gene showed high fibrinogen-binding activity (24.3%). Strains exhibiting significantly higher levels of binding to human fibrinogen belonged to a phylogenetic group of strains associated with neonatal meningitis, currently known as the ST-17 clone, that is mostly composed of serotype III strains. These findings indicate thatS. agalactiae strains possess a wide variety offbs gene content that markedly influences the ability of strains to bind to human fibrinogen. Variations in the configuration and the expression of the Fbs proteins may therefore partly explain the variability of virulence inS. agalactiae species.

infection and immunity

Evaluation of the Ability of Streptococcus agalactiae Strains Isolated from Genital and Neonatal Specimens To Bind to Human Fibrinogen and Correlation with Characteristics of the fbsA and fbsB Genes