Open AccessCryptosporidium parvum Subtilisin-Like Serine Protease (SUB1) Is Crucial for Parasite Egress from Host Cells
Author(s) -
Samantha Nava,
A. Clinton White,
Alejandro Castellanos-González
Publication year - 2019
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.00784-18
Subject(s) - biology , cryptosporidium parvum , serine protease , gene knockdown , cryptosporidium , microbiology and biotechnology , proteases , kinase , subtilisin , rna interference , gene silencing , small interfering rna , protease , virology , transfection , rna , enzyme , cell culture , gene , biochemistry , feces , genetics
Despite the severity and global burden ofCryptosporidium infection, treatments are less than optimal, and there is no effective vaccine. Egress from host cells is a key process for the completion of the life cycle of apicomplexan parasites.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom