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The enteric bacterium and intracellular human pathogenShigella causes hundreds of millions of cases of the diarrheal disease shigellosis per year worldwide.Shigella is acquired by ingestion of contaminated food or water; upon reaching the colon, the bacteria invade colonic epithelial cells, replicate intracellularly, spread to adjacent cells, and provoke an intense inflammatory response.

Human Intestinal Enteroids as a Model System of Shigella Pathogenesis