English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Factors and mechanisms determining the differences in virulence and host specificity between the zoonotic agentsChlamydia psittaci andChlamydia abortus are still largely unknown. In the present study, two strains were compared for their invasiveness, virulence, and capability of eliciting an immune response in chicken embryos. On breeding day 10, embryonated chicken eggs were inoculated with 5 × 104 inclusion-forming units. As shown by immunohistochemistry and quantitative real-time PCR,C. psittaci displayed a significantly better capability of disseminating in the chorioallantoic membrane (CAM) and internal organs thanC. abortus . The higher infectious potential ofC. psittaci in birds was underlined by significantly higher mRNA expression rates of essential chlamydial genes, such asincA ,groEL (in CAM, liver, and spleen),cpaf , andftsW (in CAM). Although the immune responses to both pathogens were similar,C. psittaci elicited higher macrophage numbers and a stronger expression of a subset of immune-related proteins. The data imply that invasiveness ofChlamydia spp. and propagation in the host are not solely dependent on the level of host immune response but, even to a greater extent, on the expression of bacterial factors related to virulence. The fact thatC. psittaci has coped far better thanC. abortus with the avian embryo's response by upregulating essential genes may be a key to understanding the mechanisms underlying host adaptation and etiopathology.

Distinct Intensity of Host-Pathogen Interactions in Chlamydia psittaci- and Chlamydia abortus-Infected Chicken Embryos