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We report here the complete genome sequence of a novel reassortant H4N2 avian influenza virus strain, A/duck/Guangxi/125D17/2012(H4N2) (GX125D17), isolated from a duck in Guangxi Province, China in 2012. We obtained the complete genome sequence of the GX125D17 virus isolation by PCR, cloning, and sequencing. Sequence analysis revealed that this H4N2 virus strain was a novel reassortant avian inuenza virus (AIV). Information about the complete genome sequence of the GX125D17 virus strain will be useful for epidemiological studies.

Full-Genome Sequence Analysis of a Natural Reassortant H4N2 Avian Influenza Virus Isolated from a Domestic Duck in Southern China