Open AccessDivergent Human Papillomavirus Associated with Recurrent Respiratory Papillomatosis with Lung Involvement
Author(s) -
Hang Yuan,
Dan Zhou,
Jingang Wang,
Richard Schlegel
Publication year - 2013
Publication title -
genome announcements
Language(s) - English
Resource type - Journals
ISSN - 2169-8287
DOI - 10.1128/genomea.00474-13
Subject(s) - recurrent respiratory papillomatosis , biology , human papillomavirus , gene duplication , lung , papillomatosis , genome , lesion , respiratory system , virology , gene , genetics , cancer research , pathology , medicine , larynx , anatomy
A divergent human papillomavirus (HPV), isolated from a lung lesion of a patient with recurrent respiratory papillomatosis, was fully cloned, sequenced, and genetically characterized. DNA analysis revealed that the HPV contained a 10.4-kb genome, with a duplication of 2,493 bp that includes partial L1-long control region (LCR)-E6-E7-partial E1 sequences.
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