Open AccessBiosynthesis of Glycosylphosphatidylinositol Is Essential to the Survival of the Protozoan Parasite Toxoplasma gondii
Author(s) -
Michael Wichroski,
Gary E. Ward
Publication year - 2003
Publication title -
eukaryotic cell
Language(s) - English
Resource type - Journals
eISSN - 1535-9786
pISSN - 1535-9778
DOI - 10.1128/ec.2.5.1132-1136.2003
Subject(s) - toxoplasma gondii , biology , endoplasmic reticulum , parasite hosting , protozoan parasite , biosynthesis , transmembrane protein , microbiology and biotechnology , apicomplexa , gene , protozoa , genetics , plasmodium falciparum , malaria , immunology , antibody , receptor , world wide web , computer science
The PIGA gene from Toxoplasma gondii has been cloned and characterized. Like mammalian PIGA, the transmembrane and C-terminal domains are sufficient to direct localization to the parasite endoplasmic reticulum. A functional copy of PIGA is required for tachyzoite viability, demonstrating that glycosylphosphatidylinositol biosynthesis is an essential process in T. gondii.
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