Open AccessAssociation of Major Histocompatibility Complex Class 1 Chain-Related Gene A Dimorphism with Type 1 Diabetes and Latent Autoimmune Diabetes in Adults in the Algerian Population
Author(s) -
Rachida Raache,
K. Belanteur,
Habiba Amroun,
Amel Benyahia,
Amel Heniche,
Malha Azzouz,
S. Mimouni,
T. Gervais,
Dominique Latinne,
A. Boudiba,
Nabila Attal,
Mohamed Chérif Abbadi
Publication year - 2012
Publication title -
clinical and vaccine immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.649
H-Index - 77
eISSN - 1556-6811
pISSN - 1556-679X
DOI - 10.1128/cvi.05473-11
Subject(s) - haplotype , human leukocyte antigen , major histocompatibility complex , genotype , allele , type 1 diabetes , diabetes mellitus , polymorphism (computer science) , immunology , biology , type 2 diabetes , autoimmune diabetes , pathogenesis , genetics , gene , endocrinology , antigen
Major histocompatibility complex class I chain-related gene A (MICA-129) dimorphism was investigated in 73 autoimmune diabetes patients (type 1 diabetes and latent autoimmune diabetes in adults) and 75 controls from Algeria. Only MICA-129 Val allele and MICA-129 Val/Val genotype frequencies were higher among patients than in the control group. Statistical analysis of the estimated extended HLA-DR-DQ-MICA haplotypes shown that individual effects of MICA alleles on HLA-DQ2-DR3-MICA-129 Val/Val and HLA-DQ8-DR4-MICA-129 Val/Val haplotypes were significantly higher in patients than in the control groups. These preliminary data might suggest a relevant role of MICA-129 Val/Val single nucleotide polymorphism (weak/weak binders of NKG2D receptor) in the pathogenesis of T1D and LADA.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom