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We report on the efficacy of the genetically engineered Candida albicans tet-NRG1 strain as an experimental live, attenuated vaccine against disseminated candidiasis in both immunocompetent and immunodeficient mice mostly dependent on T-cell immunity. This experimental vaccination model may represent an important tool to unravel the mechanisms of protective immunity during candidiasis.

clinical and vaccine immunology

Efficacy of a Genetically Engineered<i>Candida albicans tet-NRG1</i>Strain as an Experimental Live Attenuated Vaccine against Hematogenously Disseminated Candidiasis

Efficacy of a Genetically EngineeredCandida albicans tet-NRG1Strain as an Experimental Live Attenuated Vaccine against Hematogenously Disseminated Candidiasis