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Serum responses against Mycobacterium tuberculosis HSP16 were determined for children with tuberculosis (TB) and for healthy purified protein derivative (PPD)-positive and PPD-negative children. Immunoglobulin G (IgG) and IgM responses were higher for TB patients than for other groups. After chemotherapy, IgM and IgG responses decreased for TB patients and PPD-positive subjects. Monitoring of anti-M. tuberculosis HSP16 responses could assist in the management of pediatric TB.

clinical and vaccine immunology

Anti-16-Kilodalton Mycobacterial Protein Immunoglobulin M Levels in Healthy but Purified Protein Derivative-Reactive Children Decrease after Chemoprophylaxis