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Chlamydia trachomatis infection is the most prevalent bacterial sexually transmitted infection and can cause significant reproductive morbidity in women. There is insufficient knowledge of C. trachomatis -specific immune responses in humans, which could be important in guiding vaccine development efforts. In contrast, murine models have clearly demonstrated the essential role of T helper type 1 (Th1) cells, especially interferon gamma (IFN-γ)-producing CD4 + T cells, in protective immunity to chlamydia. To determine the frequency and magnitude of Th1 cytokine responses elicited to C. trachomatis infection in humans, we stimulated peripheral blood mononuclear cells from 90 chlamydia-infected women with C. trachomatis elementary bodies, Pgp3, and major outer membrane protein and measured IFN-γ-, tumor necrosis factor alpha (TNF-α)-, and interleukin-2 (IL-2)-producing CD4 + and CD8 + T-cell responses using intracellular cytokine staining. The majority of chlamydia-infected women elicited CD4 + TNF-α responses, with frequency and magnitude varying significantly depending on the C. trachomatis antigen used. CD4 + IFN-γ and IL-2 responses occurred infrequently, as did production of any of the three cytokines by CD8 + T cells. About one-third of TNF-α-producing CD4 + T cells coproduced IFN-γ or IL-2. In summary, the predominant Th1 cytokine response elicited to C. trachomatis infection in women was a CD4 + TNF-α response, not CD4 + IFN-γ, and a subset of the CD4 + TNF-α-positive cells produced a second Th1 cytokine.

clinical and vaccine immunology

The Predominant CD4 <sup>+</sup> Th1 Cytokine Elicited to Chlamydia trachomatis Infection in Women Is Tumor Necrosis Factor Alpha and Not Interferon Gamma

The Predominant CD4 + Th1 Cytokine Elicited to Chlamydia trachomatis Infection in Women Is Tumor Necrosis Factor Alpha and Not Interferon Gamma

The Predominant CD4 ⁺ Th1 Cytokine Elicited to Chlamydia trachomatis Infection in Women Is Tumor Necrosis Factor Alpha and Not Interferon Gamma