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Mycobacterium ulcerans disease, or Buruli ulcer (BU), causes significant morbidity in West Africa. In 233 consecutive, laboratory-confirmed samples from BU patients in Benin whose Mycobacterium bovis BCG scar status was known, 130 children (&lt;15 years old) and 75 adults had a neonatal BCG vaccination scar. Of 130 children with BCG scars, 10 (7.7%) had osteomyelitis, while 3 of 9 children without BCG scars (33.3%) had osteomyelitis. Our observations support the conclusion that having a BCG vaccination scar provides significant protection against M. ulcerans osteomyelitis in children with BU disease.

clinical and vaccine immunology

Prophylactic Effect of<i>Mycobacterium bovis</i>BCG Vaccination against Osteomyelitis in Children with<i>Mycobacterium ulcerans</i>Disease (Buruli Ulcer)

Prophylactic Effect ofMycobacterium bovisBCG Vaccination against Osteomyelitis in Children withMycobacterium ulceransDisease (Buruli Ulcer)